Magnesium Versus High Dose Fentanyl in Endotracheal Intubation

National Cancer Institute, Egypt

Status: Completed

Conditions: Stress Response

Treatments: Drug: Fentanyl 2Mcg/kg; Drug: Lidocaine 1.5 mg/kg; Drug: Fentanyl 4Mcg/kg; Drug: Magnesium sulfate- Fentanyl

Study type: Interventional

Funder types: Other

Identifiers

NCT04544163

AP2007-50108

Details and patient eligibility

About

this study is designed to assess the efficacy of MgSO4 versus high dose fentanyl compared to conventional anesthesia in attenuating stress response to intubation

Full description

to assess the effect of MgSO4 combined with fentanyl compared to high dose fentanyl in attenuating stress response in cancer patients undergoing surgeries under general anesthesia requiring endotracheal intubation

Enrollment: 160 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cancer patients undergoing surgery under general anesthesia requiring endotracheal intubation
• ASA I II
• 18 to 60

Exclusion criteria

• allergy to any of the used drugs
• renal or hepatic impairment
• hypertensive patients, patients with cardiovascular or cerebrovascular diseases

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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160 participants in 4 patient groups

Magnesium sulphate- Fentanyl

Experimental group

Description:

30 mg per kg MgSo4 infusion in 100 ml saline over 10 minutes

Treatment:

Drug: Magnesium sulfate- Fentanyl

Drug: Fentanyl 2Mcg/kg

Fentanyl 4 mic

Experimental group

Description:

4 mic per kg fentanyl i.v

Treatment:

Drug: Fentanyl 4Mcg/kg

Fentanyl

Active Comparator group

Description:

2 mic per kg fentanyl i.v

Treatment:

Drug: Fentanyl 2Mcg/kg

Lidocaine- Fentanyl

Experimental group

Description:

Lidocaine 1.5 mg/kg

Treatment:

Drug: Lidocaine 1.5 mg/kg

Drug: Fentanyl 2Mcg/kg