Magnet Resonance Imaging to Evaluate of Dynamic T2 Preparation Puls by Patients With Shunt or Chronic Obstructive Pulmonary Disease

Heinrich-Heine University, Duesseldorf

Status: Completed

Conditions: Dynamic T2 Preparation

Treatments: Procedure: coronary angiography; Procedure: MRI

Study type: Observational

Funder types: Other

Identifiers

NCT02449083

13-007

Details and patient eligibility

About

There is preliminary evidence that a dynamic T2 Preparations Puls sequence by cardiac magnet resonance imaging can differentiate between oxygenated and deoxygenated blood.

In adult patients with inborn heart defects this has not yet been researched. Therefore,patients with ventriculoperitoneal shunt, septal and atrio-septal shunt should be examined. Also, patients with chronic obstructive pulmonary disease should be examined.

The aim of this study is the validation of a novel magnet resonance sequence in terms of a distinction of oxygenated blood to deoxygenated blood in comparison to invasive method of measuring cardiac catheterization.

Enrollment: 80 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with atrial septal defect (ASD) or ventricular septal defect (VSD) and COPD
• written informed consent

Exclusion criteria

• patients with ST-elevation
• contraindication for MRI
• heavy kidney disease
• pregnant or breast feeding women

Trial design

80 participants in 3 patient groups

Arm 1

Description:

Patients with indication for MRI and coronary angiography

Treatment:

Procedure: coronary angiography

Procedure: MRI

Arm 2

Description:

Patients with atrioseptal or ventriculoseptal Shunt with indication to coronary angiography

Treatment:

Procedure: coronary angiography

Procedure: MRI

Arm 3

Description:

Patients with chronic obstructive pulmonary disease with indication to coronary angiography

Treatment:

Procedure: coronary angiography

Procedure: MRI