Magnetic Resonance Imaging Diffusion Tensor Tractography for Early Osteoarthritis Assessment (TRACTILAGE)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Knee Osteoarthritis

Study type: Observational

Funder types: Other; NETWORK

Identifiers

NCT03181425

DCIC1614

Details and patient eligibility

About

The aim of this study is the evaluation of new MRI tractography maps for early knee osteoarthritis assessment.

Full description

Knee osteoarthritis (OA) is a common and chronic degenerative disease of the articular cartilage. Despite recent progress in the field of cartilage imaging, no routinely used clinical imaging modality has the ability to evaluate and monitor changes in cartilage degeneration.

More and more studies report the benefits of Magnetic Resonance (MR) diffusion tensor imaging (DTI) in the study of early knee osteoarthritis and in particular the new MRI contrasts generating the Track Weighted Imaging (TWI) technique.

This observationnal, pilot, prospective, unrandomized and uncontrolled study aim to evaluate, for the first time, the new MRI tractography maps for the assessment of early knee osteoarthritis. This study doesn't modify the medical care of the patient.

Enrollment: 8 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Over 18 years of age Knee prosthetic surgery indication with cartilage excision

Exclusion criteria

Refusal to sign a non-objection form

Trial design

8 participants in 1 patient group

Imaging assessment

Description:

All subject of the study have a knee osteoarthritis (OA) and are going to have a knee prosthetic surgery with cartilage excision. Imaging measurements are conducted on human cartilage samples (2 samples per patient are selected : healthy and severely degraded).