Magnetic Resonance Imaging-guided Adaptive Radiotherapy for Large Brain Metastases

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Enrolling

Conditions: Brain Metastases

Treatments: Radiation: magnetic resonance imaging-guided adaptive radiotherapy

Study type: Observational

Funder types: Other

Identifiers

NCT06405256

BMMRIgART

Details and patient eligibility

About

This study is an ambispective cohort study to evaluate the displacement and deformation of large brain metastases (BM) treated with magnetic resonance imaging-guided adaptive radiotherapy (MRIgART)

Full description

All patients had a pathologically confirmed malignant cancer and were diagnosed with brain metastases (BM) by enhanced magnetic resonance imaging (MRI) with BM volume of 2cm and above. All patients received Unity MR-linac adaptive radiotherapy. Gross tumor volume (GTV) and organs at risk (OARs) were re-delineated for every image set and analyzed for displacement and deformation.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age ≥ 18 years; KPS score ≥ 60.
2. pathologically confirmed lung cancer.
3. diagnosed with brain metastases by enhanced MRI.
4. BM volume ≥ 2cm.
5. Anticipated time to survival>3 months.
6. Treated with Unity MR-linac.
7. Good compliance; Able to stay still in supine position for 45 minutes and above.

Exclusion criteria

1. Fail to complete radiotherapy as planned; Anticipated time to survival less than 3 months.
2. Suffer from severe back pain in supine position, unable to receive Unity MR-linac.
3. Suffer from severe claustrophobia.
4. Incomplete pre-Unity image data.

Trial design

20 participants in 1 patient group

BM patients receiving MRIgART

Description:

For it's an observational study, all patients eligible will be divided into the group "BM patients receiving MRIgART"

Treatment:

Radiation: magnetic resonance imaging-guided adaptive radiotherapy