Magnetic Resonance Imaging in Patients with Trigeminal Neuralgia

Tongji Hospital

Status: Not yet enrolling

Conditions: Trigeminal Neuralgia (TN)

Study type: Observational

Funder types: Other

Identifiers

NCT06853119

2024S240

Details and patient eligibility

About

This study intends to use MRI technology to analyze the dynamic changes and microstructure changes of the brain network in patients with trigeminal neuralgia, evaluate the blood-brain barrier and water exchange rate, and further analyze their correlation with clinical indicators, so as to explore the changes in brain structural plasticity and potential neural mechanisms

Enrollment: 120 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The diagnosis was TN according to the ICHD.
• Patients requiring surgical treatment due to ineffective or intolerant treatment with carbamazepine or oxasepine before operation;
• First surgical treatment;
• Right-handed dominant;
• There was no significant loss of sensation

Exclusion criteria

• Secondary TN;
• Associated with other types of chronic pain or neuropsychiatric disorders;
• History of head trauma or stroke or cerebrovascular ischemia;
• History of microvascular decompression or other treatments (gamma knife radiosurgery, etc.);
• Unable to cooperate independently;
• Contraindications, such as uncontrolled infection, coagulopathy, etc.;
• MRIcontraindications (e.g., pacemaker, claustrophobia, etc.)

Trial design

120 participants in 2 patient groups

Trigeminal Neuralgia Group

Description:

Patients who were diagnosed with trigeminal neuralgia (TN) according to the International Classification of Headache Disorders (ICHD) and were intolerant or ineffective to the preoperative treatment of carbamazepine or ocasepine, requiring the treatment of percutaneous balloon compression (PBC)

Health Control Group

Description:

Healthy controls matched by age, sex, etc