Magnetic Resonance Imaging in the Diagnosis of Pulmonary Hypertension

Medical University of Graz

Status: Completed

Conditions: MR Phase Contrast Velocity Imaging; Late Enhancement Patterns; Ventricular Function; Pulmonary Hypertension

Study type: Observational

Funder types: Other

Identifiers

NCT00575692

PH-06-CMR-01

Details and patient eligibility

About

The aim of the present study is to identify changes in the cardiovascular system in patients with pulmonary hypertension (PH) by magnetic resonance imaging (MRI). MRI is accepted as golden standard method for the evaluation of left and right ventricular morphology and function.

All patients who showed elevated pulmonary pressure in the right heart catheter investigation are assigned to MRI. Parameters derived from MRI are included in the clinical and therapeutic decisions. Well established as well as new MRI parameters are evaluated and compared to the results of right heart catheter. Further age-matched controls without known cardiac or pulmonary disease are investigated by native MRI.

Full description

Patients with suspected, latent and manifest PH and controls are investigated by MRI according to the following protocol in breathhold or free breathing (depending on the patients' breath-hold abilities). In case of elevated Creatinin values, no contrast agent is applied.

• Planning of cardiac views: Planning of 2-chamber view, short axes view and 4-chamber view.
• Morphological overview: Transversal and coronal Haste images
• Left and right heart functional and valve evaluation: Cine 2-chamber imaging, Multi-slice cine 4-chamber imaging, Cine Left and Right ventricular outflow tract imaging and Multi-slice cine short axes imaging covering the left and right ventricle for evaluation of EDV, ESV, SV, EF, CO and muscle mass.
• Phase Contrast Imaging: Flow measurements in the aorta, the pulmonary artery and the heart.
• Perfusion measurement.
• Late enhancement measurement: Multi-slice short axes view, multi-slice 2-chamber view and multi-slice 4-chamber view.

Enrollment: 240 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Controls without history of cardiac or pulmonary diseases
• Patients with suspected PH
• Patients with latent PH
• Patients with manifest PH

Exclusion criteria

• MRI exclusion criteria

Trial design

240 participants in 2 patient groups

PulmoHypertension

Description:

Patients with suspected, latent or manifest pulmonary hypertension

Controls

Description:

Controls without history of cardiac or pulmonary diseases