Magnetic Resonance Imaging (MRI) Solely For Liver Stereotactic Body Radiation Therapy (SBRT)

Duke University

Status: Completed

Conditions: Primary Liver Cancer; Metastatic Liver Cancer From Any Cancer Site

Study type: Observational

Funder types: Other

Identifiers

NCT02722395

Pro00071159

Details and patient eligibility

About

This study is a research and development initiative established to explore the use of magnetic resonance imaging (MRI) as a tool for managing organ motion of the liver in cancer patients planning procedures for stereotactic body radiation therapy (SBRT).

Full description

There is a potential role to systematically implement MRI to establish appropriate workflow of the implementation for tumor motion management in liver SBRT. Compared to CT, MRI has many significant advantages for radiotherapy planning, including superior tumor and soft-tissue contrast, flexible imaging orientation, freedom from radiation exposure and real-time imaging. MRI solely based liver SBRT will allow for more precise delineation of target volume, less uncertainties in treatment planning, better motion management, and potentially better treatment outcome

Enrollment: 5 patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 21
• Patients with primary stage I, II, III liver cancer or metastatic tumor in the liver from any cancer site
• Signed, specific informed consent prior to study entry
• Women of child bearing potential must have a negative serum pregnancy test

Exclusion criteria

• Any condition for which a MRI procedure is contraindicated including presence of metallic material in the body, such as pacemakers, non- MRI compatible surgical clips, shrapnel.
• Pregnant or breast-feeding women are excluded.
• Subjects who have difficulty lying flat on their back for extended periods of time

Trial design

5 participants in 1 patient group

Single arm cohort study