Magnetic Resonance Imaging of the Effect of Music Listening on Brain Activity Under Anesthesia

University of Michigan

Status and phase: Completed; Phase 4

Conditions: Healthy

Treatments: Other: Functional Magnetic Resonance Imaging (fMRI)

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT04464265

R01GM103894 (U.S. NIH Grant/Contract)

HUM00176300

Details and patient eligibility

About

This study is to better understand the systems-level neuronal mechanisms by which general anesthetics produce loss of consciousness.The researchers believe that anesthetics suppress consciousness by disrupting the functioning of large-scale brain networks that support information integration in the brain.

Enrollment: 47 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologist physical status of 1 (ASA-1), Healthy, non-smoking, no or minimal alcohol use
• Right-handed
• Body mass index (BMI) of less than 30
• English speakers

Exclusion criteria

• Medical contraindication to Magnetic Resonance Imaging (MRI) scanning
• Unable to undergo MRI scanning because of possible pregnancy
• BMI over 30
• Tattoos in the head or neck region
• Unwilling to abstain from alcohol for 24 hours prior to dosing

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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47 participants in 1 patient group

Functional Magnetic Resonance Imaging

Experimental group

Description:

While music is played Noninvasive functional magnetic resonance (fMRI) imaging will be performed at the University of Michigan Health System, University Hospital, Department of Radiology. The fMRI is done under anesthesia using propofol. The researchers will manually control the infusion of propofol to achieve target effect-site concentrations of 1.2, 1.6, 2.0, and 2.4 μg/ml in a stepwise fashion.

Treatment:

Other: Functional Magnetic Resonance Imaging (fMRI)