Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder

Nanjing Medical University

Status and phase: Unknown; Phase 4

Conditions: Major Depressive Disorder

Treatments: Behavioral: Cognitive-Behavior Therapy; Drug: SSRI antidepressants

Study type: Interventional

Funder types: Other

Identifiers

NCT01460212

QYK09184

Details and patient eligibility

About

Study hypothesis: psychotherapy and SSRI treatment effect in different brain way: psychotherapy in "up to down" way and SSRI in "down to up" way. The investigators will explore this hypothesis in major depressive disorder outpatients with Magnetic Resonance Imaging analysis in this study. Patients in different groups will be treated by psychotherapy or SSRI treatment. They will all be checked with Magnetic Resonance Imaging pro and after 12 weeks of treatment.

Full description

Patients meeting the inclusion criteria undergo an examination that included a diagnostic interview, vision test, and psychophysiological measures. Participants then undergo the baseline fMRI scan within 48 hours, after that, they will receive psychotherapy or SSRI treatment.and returned the scan once they completed the therapy.

Enrollment: 80 estimated patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• meet SCID -Ⅰ/P major depressive disorder diagnosis;
• Right handedness;
• good visual acuity.

Exclusion criteria

• neurological disease ;
• serious physical illness (e.g. heart, lung, liver, kidney or blood system disease);
• with other mental disorder;
• psychotic symptoms
• personality disorders;
• pregnancy;
• suicidal risk;
• treatment by antidepressants or other psychotropic medications within 6 months prior to the start of the trial;
• with contraindication for MRI

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

Cognitive-Behavior Therapy group

Experimental group

Description:

treatment with Cognitive-Behavior Therapy

Treatment:

Behavioral: Cognitive-Behavior Therapy

SSRI antidepressants

Active Comparator group

Description:

treatment by SSRI antidepressant

Treatment:

Drug: SSRI antidepressants