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Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder

N

Nanjing Medical University

Status and phase

Unknown
Phase 4

Conditions

Major Depressive Disorder

Treatments

Behavioral: Cognitive-Behavior Therapy
Drug: SSRI antidepressants

Study type

Interventional

Funder types

Other

Identifiers

NCT01460212
QYK09184

Details and patient eligibility

About

Study hypothesis: psychotherapy and SSRI treatment effect in different brain way: psychotherapy in "up to down" way and SSRI in "down to up" way. The investigators will explore this hypothesis in major depressive disorder outpatients with Magnetic Resonance Imaging analysis in this study. Patients in different groups will be treated by psychotherapy or SSRI treatment. They will all be checked with Magnetic Resonance Imaging pro and after 12 weeks of treatment.

Full description

Patients meeting the inclusion criteria undergo an examination that included a diagnostic interview, vision test, and psychophysiological measures. Participants then undergo the baseline fMRI scan within 48 hours, after that, they will receive psychotherapy or SSRI treatment.and returned the scan once they completed the therapy.

Enrollment

80 estimated patients

Sex

All

Ages

20 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • meet SCID -Ⅰ/P major depressive disorder diagnosis;
  • Right handedness;
  • good visual acuity.

Exclusion criteria

  • neurological disease ;
  • serious physical illness (e.g. heart, lung, liver, kidney or blood system disease);
  • with other mental disorder;
  • psychotic symptoms
  • personality disorders;
  • pregnancy;
  • suicidal risk;
  • treatment by antidepressants or other psychotropic medications within 6 months prior to the start of the trial;
  • with contraindication for MRI

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

80 participants in 2 patient groups

Cognitive-Behavior Therapy group
Experimental group
Description:
treatment with Cognitive-Behavior Therapy
Treatment:
Behavioral: Cognitive-Behavior Therapy
SSRI antidepressants
Active Comparator group
Description:
treatment by SSRI antidepressant
Treatment:
Drug: SSRI antidepressants

Trial contacts and locations

1

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Central trial contact

Chun Wang, doctor

Data sourced from clinicaltrials.gov

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