Magnetic Resonance Spectroscopic Imaging (MRS) and Tumor Perfusion of Human Glioblastoma Treated With Concurrent Radiation Therapy and Temozolomide

AHS Cancer Control Alberta

Status and phase: Completed; Phase 2; Phase 1

Conditions: Glioblastoma; Glioma

Treatments: Procedure: Functional MRI imaging and tomotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT00250211

CNS-09-0027 / ethics 21780

Details and patient eligibility

About

The purpose of this study is to learn whether 3 tesla (3T) MRI functional imaging will map a tumor more accurately allowing a more targeted delivery of radiation. The investigators hope to learn whether tomotherapy will be able to deliver higher radiation doses safely to the tumor while sparing the surrounding normal tissue.

Enrollment: 26 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically confirmed glioblastoma multiforme
• Ages 18-65
• Karnofsky Performance Scale (KPS) equal to or less than 70
• Minimal neurological deficit
• Eligible for concurrent temozolomide chemotherapy

Exclusion criteria

• Prior radiation therapy to hand or neck area, chemotherapy, or radiosensitizer

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)