Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism

Johns Hopkins University

Status: Enrolling

Conditions: Heart Failure, Congestive

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00181259

R01HL061912-14 (U.S. NIH Grant/Contract)

NA_00044690

Details and patient eligibility

About

The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.

Full description

This study uses magnetic resonance (MR) spectroscopy to study heart metabolism and function in normal subjects and patients with left ventricular hypertrophy, dilated cardiomyopathy, and those with coronary artery disease.

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age > 18 years
• Healthy subjects: no history of heart disease
• Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) <40%
• Left ventricular hypertrophy: wall thickness >1.2cm
• Coronary artery disease: >50% coronary lesion or positive stress test

Exclusion criteria

• contraindication to MRI