Magnetoencephalography by Optical Pumping Magnetometer (MEG OPM)

Centre Hospitalier Universitaire, Amiens

Status: Enrolling

Conditions: Optical Pump Magnetometer; Premature; Neonate; Magnetoencephalography

Treatments: Other: Magnetoencephalography

Study type: Interventional

Funder types: Other

Identifiers

NCT05835817

PI2021_843_0205

Details and patient eligibility

About

MagnetoEncephaloGraphy (MEG) is a method of recording brain activity with high temporal resolution and good spatial resolution, compared to current recording techniques such as ElectroEncephaloGraphy (EEG). The main limitation of MEG is its cost due to the sensors used, the Super Quantum Interference Devices (SQUID). These require a complex infrastructure from an instrumentation point of view to operate, requiring liquid helium, most often at a loss, at increasing cost. Optical Pumping Magnetometers (OPM) type sensors represent a promising alternative to SQUIDs sensors, especially since they do not require helium cooling.

The purpose of this project is to Identify biomarkers in Magnetoencephalography of normal brain development in healthy adults, premature and term newborns from "a priori" obtained by the classical technique of High Resolution EEG performed.

Enrollment: 70 estimated patients

Sex: All

Ages: 1+ day old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• For healthy adult volunteers
• Age between 18 and 65
• No pathology, no treatment
• No toxicant intake
• For term newborns
• Child between 38 and 42 weeks gestational age on the day of registration
• No pathology, no treatment
• For children born prematurely
• Child between 28 and 36 weeks gestational age on the day of registration
• No pathology, no treatment apart from routine care related to prematurity
• For pregnant women
• Pregnant with between 28 to 40 weeks gestational age on the day of registration
• No pathology, no treatment

Exclusion criteria

• Subject and Patients "not compatible" MEG. Wearers of prosthesis or pacemaker likely to generate artefacts interfering with the measurement. There is no danger to the subject, but the measurement itself may be impossible.
• Patients who cannot stand to stand still for a few minutes.
• Newborn on ventilatory assistance or infusion
• Newborn baby not meeting the age criteria

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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70 participants in 4 patient groups

Adults

Experimental group

Treatment:

Other: Magnetoencephalography

full term neonates

Experimental group

Treatment:

Other: Magnetoencephalography

premature neonates

Experimental group

Treatment:

Other: Magnetoencephalography

pregnant women

Experimental group

Treatment:

Other: Magnetoencephalography