Major Allergen in Wheat Anaphylaxis in Thai Population

Mahidol University

Status

Completed

Conditions

Anaphylaxis Exercise

Anaphylaxis Food

Wheat Allergy

Treatments

Diagnostic Test: immunoblot

Study type

Interventional

Funder types

Other

Identifiers

NCT03487315

842/2559(EC3)

Details and patient eligibility

About

To study Major allergen in Wheat anaphylaxis in Thai population
To study and compare demographic data between group of wheat anaphylaxis

Full description

Wheat is one of the most common causes in food-induced anaphylaxis and food dependent, exercised induced anaphylaxis. Gold standard for diagnose food allergy is double blind placebo control food challenge, but it is a high risk procedure. The accuracy of skin prick test and specific IgE assay showed unsatisfactory results. It might be explained by these tests may not detect all of the major allergens in wheat allergic patients. Previous studies showed that the major allergens of wheat dependent, exercised induced anaphylaxis are omega5 gliadin, followed by high molecular weight glutenin. For IgE-mediated wheat allergy, the major allergens varied among studies, including omega5 gliadin, glutenin, alpha/beta/gamma gliadin, and the water-soluble part of wheat allergens. There is no study to direct compare the major allergen between patients who have low wheat specific IgE and very high wheat specific IgE. Also, there is no data about the major allergens of wheat anaphylaxis in Thai population.

Enrollment

36 patients

Sex

All

Ages

1 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Wheat anaphylaxis patient aged 1-60 years, who received treatment at division of allergy, department of Pediatrics and Medicine, Siriraj Hospital from 2001 to 2016

Exclusion criteria