Making Activity Time for Cognitive Health (MATCH)

University of Illinois at Urbana-Champaign

Status: Completed

Conditions: Breast Cancer; Physical Activity; Cognitive Impairment; Cancer-related Problem/Condition

Treatments: Behavioral: Walking for 10 minutes; Behavioral: Walking for 20 minutes; Behavioral: Walking for 30 minutes

Study type: Interventional

Funder types: Other

Identifiers

NCT04255225

UIUC_IRB_16912

Details and patient eligibility

About

Approximately 75% of cancer survivors experience some degree of cognitive deficit throughout their cancer experience, with upwards of one third of breast cancer survivors reporting impairments up to a decade after treatment. Chemotherapy and adjuvant therapy to remove cancerous tissue can result in deficits in attention, speed of processing, memory, and quality of life. Physical activity has been associated with a number of health benefits for breast cancer survivors including improvements in cognitive function. The investigators recently reported on the beneficial effects of acute exercise, or single sessions of physical activity, on processing speed and spatial working memory in breast cancer survivors, suggesting that acute bouts of physical activity may mitigate select domains of CRCI. Specifically, survivors in this study demonstrated faster processing speed, and trended towards faster and more accurate spatial working memory, after thirty minutes of moderate-intensity walking compared to seated rest. But half an hour of walking may be challenging to certain subgroups of survivors, particularly those who are deconditioned or with significant barriers to longer walks. With a renewed focus on un-bouted physical activity and avoiding inactivity during survivorship, it is important to better understand the dose or volume of exercise responsible for providing breast cancer survivors with the greatest cognitive benefits. The investigators examined the effects of varying durations of exercise (e.g., 10, 20 and 30 minutes) on cognitive function in breast cancer survivors to identify the optimal length of acute exercise. Findings from this study will inform new guidelines for acute exercise after cancer.

Enrollment: 50 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• women over the age of 18
• diagnosis of breast cancer
• no longer undergoing treatment
• fluent in English
• no history of dementia or organic brain syndrome
• not currently pregnant
• able to walk unassisted
• no health reasons that would prevent ability to exercise
• not currently enrolled in another exercise research study
• reported trouble with memory/concentration
• physician's consent

Exclusion criteria

• male
• no diagnosis of breast cancer
• under 18 years of age
• currently undergoing treatment for breast cancer
• inability to communicate in English
• history of dementia or organic brain syndrome
• pregnant
• unable to walk unassisted
• other health reasons that may prevent ability to exercise
• enrolled in another exercise research study
• no reported trouble with memory or concentration
• non-consent of physician

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

50 participants in 3 patient groups

10-minute Treadmill Walking

Experimental group

Description:

All participants will walk on the treadmill and perform a battery of cognitive tasks immediately prior and immediately after the walking session. Participants will be randomized the length of time spent walking on the treadmill: 10, 20 or 30 minutes.

Treatment:

Behavioral: Walking for 10 minutes

20-minute Treadmill Walking

Experimental group

Description:

All participants will walk on the treadmill and perform a battery of cognitive tasks immediately prior and immediately after the walking session. Participants will be randomized the length of time spent walking on the treadmill: 10, 20 or 30 minutes.

Treatment:

Behavioral: Walking for 20 minutes

30-minute Treadmill Walking

Experimental group

Description:

All participants will walk on the treadmill and perform a battery of cognitive tasks immediately prior and immediately after the walking session. Participants will be randomized the length of time spent walking on the treadmill: 10, 20 or 30 minutes.

Treatment:

Behavioral: Walking for 30 minutes