Malnutrition in Chronic Pancreatitis, Trans-sectoral Study

University Medicine Greifswald

Status: Unknown

Conditions: Chronic Pancreatitis; Malnutrition; Sarcopenia

Treatments: Other: Intensified Nutritional Therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT04476056

BB 069/19

Details and patient eligibility

About

Malnutrition and loss of muscle mass are common in patients with chronic pancreatitis. However, there is only limited data on nutritional treatment. In this study, malnourished patients with chronic pancreatitis will receive an intensified nutritional therapy to improve nutritional status. The aim of the study is that malnutrition in patients with chronic pancreatitis can be successfully treated.

Full description

Malnutrition and sarcopenia are common complications in chronic pancreatitis leading to increased morbidity and mortality. Therefore nutritional therapy can be considered imperative. However, there is limited evidence on the treatment of malnutrition in patients with chronic pancreatitis. This study aims to investigate the effect of an intensified nutritional therapy on nutritional status in malnourished patients with chronic pancreatitis. By testing feasibility of this intensified therapy valuable recommendations for future treatment of malnutrition in patients with chronic pancreatitis can be derived.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic pancreatitis verified by histology or imaging modality (endoscopic ultrasound, computed tomography, magnetic resonance imaging, magnetic resonance cholangiopancreatography)
• Diagnosis of malnutrition

Exclusion criteria

• Pregnant or breast feeding
• Implanted defibrillator or pacemaker
• History of pancreatic Cancer
• Any other malignant tumor disease within the last 3 years
• Concomitant liver cirrhosis

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

Chronic Pancreatitis + Malnutrition

Experimental group

Description:

Malnourished patients with chronic pancreatitis will receive intensified nutritional therapy for 6 months.

Treatment:

Other: Intensified Nutritional Therapy