Management in Intensive Care Unit of Life-threatening Keto-Acidosis (MILKA)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Ketoacidosis

Study type: Observational

Funder types: Other

Identifiers

NCT05488262

2022-A00455-38

Details and patient eligibility

About

Patients hospitalized in intensive care between January 2014 and December 2023 for ketoacidosis complicated by organ failure in participating departments.

Full description

Analysis of patients with International Statistical Classification of Diseases and Related Health Problems coding compatible with inclusion

• Selection of patients eligible for inclusion based on review of medical records (verification of inclusion and non-inclusion criteria)
• Telephone contact and sending of the information letter on participation in the study and research of the patient's non-opposition to his participation and the processing of his data.
• Collection of retrospective data
• Phone call to collect prospective data

Enrollment: 70 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Major (age ≥ 18 years old)
• Hospitalized in intensive care between January 2014 and December 2023 for ketoacidosis complicated by organ failure in the participating departments.
• Diagnosis of ketoacidosis judged to be the main cause of the severity of the clinical condition.
• Blood potential hydrogen < 7.15 and bicarbonates < 10mmol/L in the first 12 hours of treatment.
• Presenting at least one of the 3 organ failures during hospitalization among:
• Use of extra-renal purification for acute renal failure
• Administration of pressor amines
• Use of mechanical ventilation

Exclusion criteria

• Metabolic acidosis primarily of an origin other than ketonic
• Refusal to participate or opposition to the processing of their data
• Patient under guardianship or curators