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Management of Drug Hypersensitivity in Children (DHC)

University Hospitals (UH) logo

University Hospitals (UH)

Status

Unknown

Conditions

Drug Hypersensitivity

Study type

Observational

Funder types

Other

Identifiers

NCT02031120
UGeneva 13-006

Details and patient eligibility

About

The aim of this study is (1) to assess the incidence of suspected drug allergies in a pediatric hospital and the proportion in which these reactions are confirmed to be allergic; (2) to evaluate the diagnostic values of the different allergy tests available; (3) to investigate the pathophysiology of drug allergies, particularly by investigating the role of viruses, and by performing HLA typing and a gene expression profile both in the acute phase of the reaction and 2 months later.

Enrollment

250 estimated patients

Sex

All

Ages

Under 16 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Participation will be proposed to any children (0 to 16 years) receiving one or several drug(s) and developing one of the following clinical manifestations: urticaria, maculopapular rash, bullous eruption, flush, anaphylaxis, serum sickness-like disease, SJS, TEN, DRESS or fever linked to drug intake.

Exclusion criteria

  • Patients will be excluded if the symptoms occur more than 72 hours after any treatment was stopped or if the symptoms are clearly linked to another cause (measles, rubeola, roseola, varicella, fifth disease, Gianotti-Crosti syndrome, scarlet fever, Gibert's pityriasis or food allergy).

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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