Management of Patients With Alpha-1 Antitrypsin Deficiency Associated Emphysema

Assistance Publique - Hôpitaux de Paris

Status: Unknown

Conditions: Emphysema; Alpha 1-Antitrypsin Deficiency

Study type: Observational

Funder types: Other

Identifiers

NCT00700934

001

Details and patient eligibility

About

The aim of this study is to describe the natural history of patients with alpha-1 antitrypsin associated emphysema and to figure out associated prognostic factors.

Full description

All patients who suffer from this disease are followed every 6 months during a 5 years period. FEV1 decline is the primary endpoint. Quality of life assessed using the Saint George's Respiratory Questionary is recorded too.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Serum alpha one antitrypsin < 0.8 g/l
• Emphysema diagnosed by CT scan
• Adult
• Obstructive disorder

Exclusion criteria

• Liver or lung transplantation