Management of Sleep Apnoea Syndrome (SAS) in Patients With Vasovagal Syncope (VVS) (VVS-SAS)

PEAS (Pole d'Exploration des Apnees du Sommeil)

Status: Unknown

Conditions: Syncope, Vasovagal; Sleep Apnea Syndromes

Treatments: Other: Sleep apnea treatment

Study type: Observational

Funder types: Other

Identifiers

NCT04294524

2017-A03169-44 (Registry Identifier)

Details and patient eligibility

About

This is a multi-centre, registry-based study whose primary objective is to evaluate the effect of treatment for sleep apnoea syndrome (SAS) on the number of syncope/malaise episodes in a population suffering from both idiopathic, recurrent vasovagal syncope/malaises and SAS.

Full description

Treatment for sleep apnoea syndrome includes continuous positive airway pressure (CPAP) or a mandibular advancement device (MAD). Additional routine follow-up includes 24 hour holter monitoring on a yearly basis, polysomnography on a yearly basis, multiple sleep latency tests, table tilt tests.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Obstructive sleep apnoea syndrome (>15 respiratory micro awakenings per hour of sleep) with an indication for treatment
• Recurring vasovagal syncope episodes defined as follows: at least three vasovagal syncopes during the last two years - OR- symptoms of orthostatic intolerance occurring in the last 6 months (Symptoms are triggered by orthostatism and can include malaises without loss of consciousness, asthenia, dizziness, visual disturbances, tinnitus, palpitations, headache, limitations of physical activity)

Exclusion criteria

• Pathology that may explain syncope symptoms
• Cardiopathy
• Known disautonomia
• Hypotension of known origin
• Adrenal insufficiency
• Thyroid disorder
• History of sudden death in a first degree family member