Management of the Idiopathic Overactive Bladder With Botulinum Toxin: Systematic Review

Clínica Infantil Colsubsidio

Status: Unknown

Conditions: Urinary Bladder, Overactive

Treatments: Other: Other interventions analyzed according to protocol; Drug: Intradetrusor Injection of Type-A Botulinum Toxin

Study type: Observational

Funder types: Other

Identifiers

NCT01750645

COLS-201207

Details and patient eligibility

About

Overactive bladder is defined as a syndrome composed of urgency, increased urinary frequency, and sometimes urinary incontinence; its etiology may be characterized as neurogenic or non-neurogenic (i.e., idiopathic). This illness has a great impact in quality of life and one of the available treatments is the injection of Botulinum Toxin. This study aims to review the efficacy and safety of type-A Botulinum Toxin in the management of Idiopathic Overactive Bladder. A systematic search was performed in MEDLINE, EMBASE, CENTRAL and LILACS, and the controlled randomized clinical trials were chosen to review with the CONSORT criteria by independent reviewers. Outcomes analyzed were the efficacy of the intervention for relieving the symptoms (urgency, frequency and urgency incontinence), adverse events to treatment, change in quality of life and urodynamic measures.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Controlled randomized clinical trials
• Adult patients diagnosed with idiopathic overactive bladder
• Language of the study: english

Exclusion criteria

• Diagnosis of neurogenic overactive bladder
• Patients under 18 years old
• Use of Type-B Botulinum Toxin as the intervention
• Other types of studies

Trial design

0 participants in 2 patient groups

Intervention Group

Treatment:

Drug: Intradetrusor Injection of Type-A Botulinum Toxin

Control Group

Treatment:

Other: Other interventions analyzed according to protocol