Manipulation of Dietary Protein and the Anabolic Response (PRO-ADAPT)

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Focus: Anabolic Response to Food Intake in Young Individuals; Condition Relevance: Skeletal Muscle Health, Sarcopenia

Treatments: Dietary Supplement: High protein intake; Other: Placebo comparator

Study type: Interventional

Funder types: Other

Identifiers

NCT01820975

METC 12-3-067

Details and patient eligibility

About

In the present study, the effect of habitual dietary protein on the anabolic response will be investigated.

Enrollment: 28 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Males
• Aged between 18-35 years
• Healthy, recreationally active
• BMI < 30 kg/m2

Exclusion criteria

• Smoking
• Allergies to milk proteins (whey or casein)
• Vegetarians
• Diagnosed GI tract diseases
• Female
• Arthritic conditions
• A history of neuromuscular problems
• Previous participation in amino acid tracer studies
• Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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28 participants in 2 patient groups, including a placebo group

High protein intake

Experimental group

Description:

High protein intake: large bolus of protein in teh diet the day before testing

Treatment:

Dietary Supplement: High protein intake

No protein intake

Placebo Comparator group

Description:

No protein in the diet the day before testing

Treatment:

Other: Placebo comparator