Mannitol (Aridol) and Methacholine (Provocholine) Responsiveness

University of Saskatchewan

Status and phase: Completed; Phase 4

Conditions: Asthma

Treatments: Drug: Methacholine (Provocholine); Drug: Mannitol (Aridol)

Study type: Interventional

Funder types: Other

Identifiers

NCT01642745

IIS-A-522

Details and patient eligibility

About

The study will compare the airway responses to two bronchoconstricting agents, mannitol and methacholine.

Enrollment: 20 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• stable controlled asthma

Exclusion criteria

• pregnancy
• use of asthma therapies other than bronchodilator therapy

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 3 patient groups

Methacholine (Provocholine) with deep inhalation

Experimental group

Treatment:

Drug: Methacholine (Provocholine)

Drug: Methacholine (Provocholine)

Mannitol (Aridol)

Experimental group

Treatment:

Drug: Mannitol (Aridol)

Methacholine (Provocholine) tidal breathing

Active Comparator group

Treatment:

Drug: Methacholine (Provocholine)

Drug: Methacholine (Provocholine)