Mantle Irradiation for Hodgkin's Disease

Dana-Farber Cancer Institute

Status and phase: Completed; Phase 2

Conditions: Hodgkin's Disease

Treatments: Procedure: Mantle irradiation

Study type: Interventional

Funder types: Other

Identifiers

NCT00165269

92-035

Details and patient eligibility

About

The purpose of this study it to evaluate the effectiveness of radiation therapy limited to above the diaphragm in patients with pathological stage IA-IIA Hodgkin's disease.

Full description

• Eligble patients will receive a course of radiation therapy directed to above the diaphragm only.
• Patients would have bloodwork and chest x-rays performed 4 times per year for the first two years, 3 times per year for the third year, and 2 times per year for the fourth and fifth years. After five years, yearly check-ups are performed.
• In addition to the above follow-up, patients will receive, once or twice a year for the first 5 years, an abdominal-pelvic CT scan and/or gallium scan.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pathologically Stage IA-IIA Hodgkin's disease
• A negative staging laparotomy including splenectomy, biopsies of liver, paraortic nodal biopsies and palpitation of upper pelvic nodes
• 18 years of age or older

Exclusion criteria

• Patients with large mediastinal adenopathy
• Patients with LD histology
• Patients with "B" symptoms
• Positive laparotomy
• Subcarinal, hilar, or cardiac lymph node involvement

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)