Manual Dexterity Modifications After Application of tSMS Over the Primary Motor Cortex (M1)

Universidad Rey Juan Carlos

Status

Unknown

Conditions

Stroke

Manual Dexterity

Neurologic Disorder

Treatments

Device: Sham tSMS

Device: tSMS

Study type

Interventional

Funder types

Other

Identifiers

NCT05260190

URJCtSMS100222

Details and patient eligibility

About

Transcranial static magnetic field stimulation (tSMS) is a novel brain stimulation technique that has been shown to be safe and effective in modifying biological parameters when applied to the cerebral cortex. Its application decreases cortical excitability, regardless of the polarity of the magnetic field, reducing the amplitude of motor evoked potentials (MEP). tSMS is presented as a potentially useful tool in the management of the interhemispheric inhibition, a condition present in neurological pathologies such as stroke or multiple sclerosis. Despite having demonstrated neurophysiological effects in previous studies, the effects of tSMS application on force production and manual dexterity, have not yet been clearly established.

The present study aims to evaluate changes in force production, manual dexterity, and fatigue after unilateral application of a tSMS session on the primary motor cortex (M1). It is hypothesized that the application of tSMS will momentarily decrease the parameters of strength and manual dexterity in the upper limb contralateral to the stimulated cortex, without changes in the strength and dexterity of the unstimulated hemibody. These parameters may show an increase in the unstimulated hemibody. If the hypothesis is confirmed, it could be considered a valid treatment for health conditions presenting interhemispheric inhibition.

Enrollment

44 estimated patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age between 18 and 60 years.
Absence of cognitive impairment.
Adequate understanding of verbal and written information, sufficient to complete the tests.

Exclusion criteria

Presence of metallic implants (e.g., neurostimulator, pacemaker, cochlear implant, or metallic elements in the head or around the eyes).
Diagnosis of epilepsy or being under treatment with antiepileptic drugs.
Diagnosis of unstable cardiovascular disease.
Diagnosis of any disease or condition that may interfere with this study.
Use of drugs that may influence with neuromuscular function (muscle relaxants or some analgesics...).