Manual Therapy Versus Exercise on Knee Osteoarthritis

Texas Tech University Health Sciences Center

Status and phase: Terminated; Phase 2

Conditions: Knee Osteoarthritis

Treatments: Procedure: Manual Therapy; Behavioral: Therapeutic Exercise; Behavioral: Video Observation

Study type: Interventional

Funder types: Other

Identifiers

NCT00988468

L10-004

Details and patient eligibility

About

Earlier research has shown that exercising while receiving manual therapy improves function and reduces pain in people with knee osteoarthritis. However, very little is known about the mechanisms by which manual therapy and exercise reduce pain and improve function. This study will ask subjects with knee osteoarthritis to receive one of the following interventions: (1) no treatment, (2) exercise only, or (3) manual therapy only. Measures will be taken of the patient's knee range of motion, knee swelling and pain before and after receiving the intervention. These measures will be analyzed to determine what effect exercise and manual therapy applied to the knee have on improving knee range of motion and reducing knee pain and swelling. Swelling will be measured using an ultrasound device which is used to take pictures inside the knee. This type of ultrasound measurement is painless and harmless.

Enrollment: 1 patient

Sex: All

Ages: 18 to 89 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosis of knee osteoarthritis.

Exclusion criteria

• Inability to ambulate at least 100 feet, ride a stationary bicycle for at least 10 minutes, or lie in the prone position for at least 10 minutes,
• Intra-articular knee injection within one month of study inception,
• A history of exercise induced or uncontrolled angina within three months of the study entry,
• Severe dyspnea at rest,
• Previous bilateral total knee arthroplasty,
• Pregnancy, OR
• The absence of knee pain at the time of recruitment for the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

1 participants in 3 patient groups, including a placebo group

Manual Therapy

Experimental group

Description:

Subjects will receive oscillatory (grade 1 \& 2) manual knee mobilization for 15 minutes at various knee range of motion positions.

Treatment:

Procedure: Manual Therapy

Therapeutic Exercise

Experimental group

Description:

Subjects will perform 15 minutes of combined resistance exercise and aerobic exercise.

Treatment:

Behavioral: Therapeutic Exercise

Control

Placebo Comparator group

Description:

Subjects will watch a 15 minute instructional video on a health topic.

Treatment:

Behavioral: Video Observation