ClinicalTrials.Veeva

Menu

Manual vs Amigo SmartTouch Atrial Fibrillation Study (MAST-AF)

U

University of Leicester

Status

Completed

Conditions

Atrial Fibrillation

Treatments

Procedure: Catheter ablation for atrial fibrillation, manual
Device: Ablation using Amigo remote catheter system

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

Atrial fibrillation is a common form of heart rhythm disturbance that for some patients is treated by catheter ablation (making an ablation lesion or burn inside the heart using a fine wire (catheter)). A new system for manipulating the catheters has recently been introduced into clinical practice (the Amigo Remote Catheter System (RCS)). This trial is designed to answer two primary questions: a) is the contact force (the force with which the catheter comes into contact with the heart) any different using the RCS to manual techniques,and b)are the resulting ablation lesions within the heart any different in terms of the volume and contiguity of the lesions produced. Additionally the investigators aim to determine how the two techniques compare in success (the proportion of patients whose heart rhythm disturbance is corrected by the procedure).

Full description

The trial aims to recruit 50 patients, randomised into two groups, to have ablation for atrial fibrillation performed either using the RCS, or manually. Contact force information will be collected during the procedure, but the operators will be blinded to this information. Patients will have follow-up to include post-procedural cardiac magnetic resonance imaging and ambulatory electrocardiograms.

Enrollment

50 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • atrial fibrillation
  • scheduled for catheter ablation

Exclusion criteria

  • contraindication to magnetic resonance imaging
  • pregnancy
  • life expectancy of less than six months
  • participation in another trial that would conflict with this trial

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

50 participants in 2 patient groups

Manual ablation
Active Comparator group
Description:
Patients will have their ablation performed manually.
Treatment:
Procedure: Catheter ablation for atrial fibrillation, manual
Ablation using remote catheter system
Active Comparator group
Description:
Ablation for atrial fibrillation using the Amigo remote catheter system
Treatment:
Device: Ablation using Amigo remote catheter system

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2026 Veeva Systems