Manually Controlled Infusion Vs Target Controlled Infusion for StrokeThrombectomy (HASTE)

University of Padova

Status: Withdrawn

Conditions: Hemodynamic Instability; Stroke/Brain Attack; Stroke, Ischemic; Anesthesia

Treatments: Procedure: TCI; Procedure: Manual induction

Study type: Interventional

Funder types: Other

Identifiers

NCT05570682

HASTE

Details and patient eligibility

About

The goal of this randomized controlled trial is to compare manual general anesthesia induction to general anesthesia induction guided by target controlled infusion system in cerebral ischemic stroke

The main questions it aims to answer are:

• Does target controlled infusion has a more favorauble hemodynamic profile than manual general anesthesia induction?
• Do patients receiving general anesthesia with target controlled infusion system have a more favourable outcome? Participants will receive general anesthesia induction with a target controlled infusion system and will be compared to patients receiving manual general anesthesia induction.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Age ≥ 18 years;
• Anterior Cerebral Circulation Stroke
• Patient eligible for mechanical trombectomy
• mRS ≤ 2;
• Fasting patients (>6 h solid, >2 hours liquids)
• Glashow Coma Scale more than seven.

Exclusion criteria

• Patient in general anesthesia at hospital arrival
• Associated hemorrhagic stroke

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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0 participants in 2 patient groups

Manual induction

Active Comparator group

Description:

General Anesthesia induction: Fentanyl 2 mcg/kg, Propofol 2 mg/kg, Rocuronium 0.6 mg/kg General Anesthesia mainteneance: Propofol 4-6 mg/kg/h to keep an adequate sedation level (BIS between 40-60; entropy between 40-60)

Treatment:

Procedure: Manual induction

Target Controlled Induction

Experimental group

Description:

General Anesthesia induction: Fentanyl 2 mcg/kg, Propofol TCI with Schneider site effect model starting from 2 mcg/ml and increasing the dose untile loss of consciousness, Rocuronium 0.6 mg/kg. General Anesthesia mainteneance: Propofol TCI with Schneider site effect model in order to keep an adequate sedation level (BIS between 40-60; entropy between 40-60)

Treatment:

Procedure: TCI