Mapping Epileptic Networks Using Multimodal Imaging (CREIM)

Imagine Institute

Status

Enrolling

Conditions

Epilepsy in Children

Treatments

Other: Secondary data collection

Study type

Observational

Funder types

Other

Identifiers

NCT06202976

IM-RCM-2017-02

Details and patient eligibility

About

Currently, mapping the epileptogenic zone is based on a comprehensive preoperative assessment involving clinical, imaging and electrophysiological examinations.

To reduce the need for invasive stereoelectroencephalography (SEEG) explorations, electrophysiological and imaging methods have been developed, such as resting-state functional MRI (fMRI) coupled with electroencephalogram and arterial spin-labeling perfusion MRI (ASL-MRI).

It has been published that these new methods enable precise delineation of the epileptogenic zone and better preparation for surgery.

The aim is to determine whether, in children with focal lesional epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG enables precise identification of the epileptogenic zone to be defined by SEEG, the current reference examination.

Enrollment

75 estimated patients

Sex

All

Ages

Under 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Be under 18 years of age on the day of inclusion.
Present with one of the following forms of epilepsy:
- refractory focal lesional epilepsy
- rare non-lesional epilepsy
Present abnormalities (spikes) on the intercritical EEG
Have been selected by the "Epilepsy" multidisciplinary staff.
In the case of refractory lesional epilepsy, be required to perform an EEG-video recording using intracranial electrodes (SEEG) as part of the pre-surgical workup.
Be affiliated to a health insurance scheme.