Mapping Mood in the Subthalamic Nucleus in Parkinson's Disease (PD) (MOOD-D)

The Washington University

Status: Completed

Conditions: Parkinson's Disease; Depression; Anxiety

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00847431

R01NS058797-05 (U.S. NIH Grant/Contract)

08-0354

Details and patient eligibility

About

The goal of this study is to determine the vulnerability of mood-related neurocircuitry in Parkinson Disease (PD) using deep brain stimulation of the subthalamic nucleus (STN DBS).

Enrollment: 81 patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for STN-DBS subjects:

• Age 40 or older
• DBS STN Surgery in past 2 to 36 months
• Ability to tolerate turning off Stimulators
• Ability to read and comprehend questions
• English speaking

Exclusion Criteria for STN-DBS subjects:

• Other severe complications post surgery: stroke, seizure, major loss of consciousness, other brain trauma/surgery, or head injuries(i.e. near drowning), encephalitis, or hydrocephalus, blindness, deafness
• Clinically determined Dementia ( Most recent MMSE score of >24)

Inclusion Criteria for Control subject:

• Age 40 or older
• Ability to read and comprehend questions
• English speaking

Exclusion Criteria for Control subject:

• Other severe complications post surgery: stroke, seizure, major loss of consciousness, other brain trauma/surgery, or head injuries(i.e. near drowning), encephalitis, or hydrocephalus, blindness, deafness
• Clinically determined Dementia ( Most recent MMSE score of >24)
• Plans to have DBS STN surgery in the next 24 months

Trial design

81 participants in 2 patient groups

STN DBS Group

Description:

PD patients with deep brain stimulators in the subthalamic nucleus. Subjects within this group will be placed into either a 1 contact group, or 2 contact group, depending on contact location requirements for this study.

Control Group

Description:

PD patients without deep brain stimulator surgery, with similar symptoms to the study group.