Mapping of Electrical Properties in the Brain
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About
This study evaluates imaging methods for monitoring neural and electrical activity in the brain for improving clinical diagnosis.
Full description
PRIMARY OBJECTIVES:
I. Optimize pulse sequence acquisitions for diffusion imaging on clinical MRI vendor systems.
II. Develop image-based MRI models (including diffusion-based MRI) that accurately depict the multi-regional electrical properties in the brain (e.g., resistivity, current) to inform of neural integrity and function (including white matter tract integrity) in diseased and non-diseased states.
III. Compare/correlate image-based MRI models (e.g., diffusion) with existing structural, physiologic, and functional MRI methods (e.g., tensor imaging, fMRI, DSC-MRI, etc).
IV. Further train image-based models/measurements with loco-regional benchmarks including (but not exclusive to) electrophysiologic monitoring, functional and structural tissue assays (from available biopsies), and correlative clinical features (e.g., histology, outcomes, treatment, etc).
OUTLINE: This is an observational study.
Participants complete a survey and undergo MRI on study.
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Inclusion criteria
- Aim 1: normal healthy volunteers
- Aim 2, 3, 4: participants included in IRB 16-002424, including those that have undergone surgical biopsy/resection for suspected or known glioma
Exclusion criteria
- Healthy volunteer unable to have an MRI
Trial design
120 participants in 1 patient group
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Central trial contact
Clinical Trials Referral Office
Data sourced from clinicaltrials.gov
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