Mapping of Vestibular Centers Activation Using fMRI in Patients With Vestibular Schwannoma

Marketa Bonaventurova

Status: Active, not recruiting

Conditions: Healthy; Unilateral Vestibular Deficit; Vestibular Schwannoma

Treatments: Procedure: vestibular schwannoma resection

Study type: Interventional

Funder types: Other

Identifiers

NCT07130851

EK-279.4/24

Details and patient eligibility

About

The goal of this clinical trial is to visualize the possible activation of vestibular centers in the brain using in patiens with unilateral vestibular damage, specifically in patients after vestibular schwannoma surgery.

The main questions it aims to answer are:

1. Is there a difference in the proces sof activation of vestibular centers in patients with unilateral vestibular disorder and healthy subjects.
2. Are we able to effect this activation with our postoperative treatment? Researchers will compare the obtained results between patients with unilateral vestibular disorder and healthy controls.

Participants will be asked to fill out the set of questionaires, to undergo clinical objective vestibular examnation and examination in magnetic resonance.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• vestibular schwannoma

Exclusion criteria

• claustrophobia, visual impairment

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Vetibular schwannoma patients

Experimental group

Description:

Patients with vestibular schwannoma undergoing surgical removal of the tumor one day before the surgery: objective methods videoHead Impulse test, cervical vestibular evoked myogenic potentials, air calorics, clinical otoneurologic examination, functional magnetic resonance subjective methods: questionnaires (DHI,..) one week after the surgery: objective methods videoHead Impulse test, clinical otoneurologic examination, functional magnetic resonance subjective methods: questionnaires (DHI,..)

Treatment:

Procedure: vestibular schwannoma resection

Healthy controls

No Intervention group

Description:

The healty patients without the history of vestibular disorder. objective methods videoHead Impulse test, cervical vestibular evoked myogenic potentials, functional magnetic resonance subjective methods: questionnaires (DHI,..)