Marijuana Use, Strength Training, and Alcohol Consumption (MUSTAC) Study

University of Florida

Status: Completed

Conditions: Chronic Pain

Treatments: Behavioral: Eccentric Biceps Flexion; Behavioral: Concentric Biceps Flexion

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT04791917

00045887 (Other Grant/Funding Number)

AGR DTD 02-17-2020 (Other Grant/Funding Number)

UFCAREDAG002 (Other Grant/Funding Number)

1F31AA028696-01A1 (U.S. NIH Grant/Contract)

IRB202000058-N

Details and patient eligibility

About

Self-medication of pain by consuming alcohol and marijuana is common. However, the research regarding pain as a determinant for alcohol and marijuana use has relied on laboratory pain induction paradigms with limited clinical relevance. The study will assess demand for alcohol and marijuana before and after delayed onset muscle soreness (DOMS) induction in co-users. This will provide a clinically relevant, but time-limited, model for the effects of musculoskeletal pain on demand.

Enrollment: 51 patients

Sex: All

Ages: 21 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age ≥ 21 years;
• English-speaking
• Self-identify as White/Caucasian or Black/African American
• Own a smartphone with cellular/data plan
• Regularly co-use alcohol and smoked marijuana as indicated by scores of ≥3 on item 1 of the CUDIT-R and AUDIT.
• Willing and able to give informed consent

Exclusion criteria

• Participation in biceps-specific conditioning program in the past 6 months*
• Self-reported wrist/hand, elbow, or shoulder pain the past 3 months
• Chronic medical condition that may affect pain perception (e.g. diabetes, fibromyalgia, headaches)
• Self-reported kidney dysfunction, muscle damage, or major psychiatric disorder
• Medical marijuana prescription
• Consumption of marijuana using only non-inhalational methods (e.g. edibles, tinctures, or cannabidiol oil)
• Score of ≥ 10 on Patient Health Questionnaire-9 (moderate depression)
• Women who are pregnant, trying to become pregnant, or breastfeeding

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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51 participants in 2 patient groups

Delayed Onset Muscle Soreness Induction

Experimental group

Description:

Participants will complete an exercise session designed to induce delayed onset muscle soreness in the biceps

Treatment:

Behavioral: Eccentric Biceps Flexion

Sham Delayed Onset Muscle Soreness Induction

Sham Comparator group

Description:

Participants will complete an exercise session that is unlikely to induce delayed onset muscle soreness in the biceps

Treatment:

Behavioral: Concentric Biceps Flexion