Markers in Follicular Fluid and in Embryo Culture Medium as a Marker of Oocyte and Embryo Quality

Israel Healthcare Foundation

Status: Unknown

Conditions: Infertility/Sterility

Study type: Observational

Funder types: Other

Identifiers

NCT03350009

CMC-16-0163-CTIL

Details and patient eligibility

About

Assessment of the quality of follicular fluid and early embryo via chemical markers.

Full description

The selectin of an embryo for transfer is currently based on detailed morphological assessment and scoring system. morhpokinetics introduced recently to IVF laboratories can define annotations and provide an algorithm for optimal cleavage rates and embryonic development. however more data and validations are requested when it comes to choosing the best single embryo from a cohort of available similarly graded embryos. Consequently, non-invasive quantitative methods for embryo selection prior to transfer have been sought. In the current study metabolic profile of follicular fluid and the embryos produced in IVF procedure will be assessed

Enrollment: 220 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients undergoing IVF procedures at Carmel Medical Center and are able to sign an informed consent form.
• Female patients age 18-45

Exclusion criteria

• Women with any malignancy
• Patient's request to be withdrawn from the study.

Trial design

220 participants in 2 patient groups

High and low grade embryos

Description:

The distribution for the high and low grade embryos is based on common morphological grading criteria.

High and low quality follicles

Description:

The distribution for the high and low grade oocytes is based on common morphological grading criteria and on different features of the participants such as age.