Markers of Airway Inflammation in BAL Fluid From Children With Asthma

National Jewish Health

Status: Completed

Conditions: Asthma

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT00838552

NJ HS-2178

Details and patient eligibility

About

The study compares the biochemical markers in bronchoalveolar lavage samples from asthmatic children to those markers found in non-asthmatic children with other respiratory diseases. The investigators hypothesize that certain markers will be associated specifically with asthma.

Enrollment: 103 patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years of age or younger
• Scheduled for bronchoscopy at National Jewish Health for persistent asthma, persistent, poorly controlled wheezing, chronic cough, GERD, atelectasis, bronchopulmonary dysplasia, infection.
• Consent and assent from parent and patient [if appropriate].

Exclusion criteria

• Unwillingness to consent/assent to retrieval of BAL fluid for research analysis.

Trial design

103 participants in 2 patient groups

1 Asthma subjects

Description:

Children with asthma undergoing clinically indicated bronchoscopy at National Jewish Health.

2 Non-asthma subjects

Description:

Children with other respiratory diseases than asthma undergoing clinically indicated bronchoscopy at National Jewish Health.