Mass Spectral Fingerprinting in Lung Cancer

University of Zurich (UZH)

Status: Active, not recruiting

Conditions: Lung Cancer

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT02781857

KEK-ZH-Nr.2015-0607

Details and patient eligibility

About

To answer the question whether a disease specific profile of breath in patients with lung cancer can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.

Enrollment: 393 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed lung cancer based on cytological or histological analysis.
• Group A: any type of lung cancer eligible for surgical resection (up to TNM stage IIIa).
• Group B: any type of lung cancer (small-cell carcinoma, non-small-cell carcinoma) not amenable for surgical resection.
• Group C: matched controls.
• Age between 18 and 85 years at study entry

Exclusion criteria

• Another 'active' secondary malignant disease (e.g. breast cancer, colon carcinoma) in group A and B, presence of any active malignant disease in group C (based on personal information).
• Acute inflammatory disease (e.g. common cold) within the last 4 weeks.
• Any other acute lung disease which affects breath measurements
• Acute or chronic hepatic disease.
• Renal failure or renal replacement therapy.

Trial design

393 participants in 2 patient groups

100 patients with lung cancer

Description:

* Group A: 70 patients with any type of lung cancer eligible for lung cancer surgery * Group B: 30 patients with any type of lung cancer not eligible to surgery (small-cell carcinoma, squamous cell carcinoma, adenocarcinoma, large-cell carcinoma).

Treatment:

Other: No intervention

60 controls

Description:

60 controls (group C) matched for age, gender, smoking history.

Treatment:

Other: No intervention