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Mass Spectral Fingerprinting in Lung Cancer

University of Zurich (UZH) logo

University of Zurich (UZH)

Status

Active, not recruiting

Conditions

Lung Cancer

Treatments

Other: No intervention

Study type

Observational

Funder types

Other

Identifiers

NCT02781857
KEK-ZH-Nr.2015-0607

Details and patient eligibility

About

To answer the question whether a disease specific profile of breath in patients with lung cancer can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.

Enrollment

393 patients

Sex

All

Ages

18 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Confirmed lung cancer based on cytological or histological analysis.
  • Group A: any type of lung cancer eligible for surgical resection (up to TNM stage IIIa).
  • Group B: any type of lung cancer (small-cell carcinoma, non-small-cell carcinoma) not amenable for surgical resection.
  • Group C: matched controls.
  • Age between 18 and 85 years at study entry

Exclusion criteria

  • Another 'active' secondary malignant disease (e.g. breast cancer, colon carcinoma) in group A and B, presence of any active malignant disease in group C (based on personal information).
  • Acute inflammatory disease (e.g. common cold) within the last 4 weeks.
  • Any other acute lung disease which affects breath measurements
  • Acute or chronic hepatic disease.
  • Renal failure or renal replacement therapy.

Trial design

393 participants in 2 patient groups

100 patients with lung cancer
Description:
* Group A: 70 patients with any type of lung cancer eligible for lung cancer surgery * Group B: 30 patients with any type of lung cancer not eligible to surgery (small-cell carcinoma, squamous cell carcinoma, adenocarcinoma, large-cell carcinoma).
Treatment:
Other: No intervention
60 controls
Description:
60 controls (group C) matched for age, gender, smoking history.
Treatment:
Other: No intervention

Trial contacts and locations

1

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Central trial contact

Malcolm Kohler, Prof. MD; Felix Schmidt, RpH

Data sourced from clinicaltrials.gov

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