Massive Transfusion in Trauma Patient Registry

Methodist Health System

Status: Enrolling

Conditions: Trauma

Treatments: Behavioral: blood products as a part of Massive Transfusion Protocol

Study type: Observational

Funder types: Other

Identifiers

NCT06136715

029.TRA.2023.D

Details and patient eligibility

About

The early use of blood products as a part of Massive Transfusion Protocol (MTP) during trauma resuscitation has been increasingly supported by providers and backed by the literature. However, the incidence of hypocalcemia during MTP has also been recorded and continues to be studied as an exacerbating factor in coagulopathy during trauma.

Full description

Although initially it was thought that the coagulopathy was due to the trauma itself, studies suggest that it is worsened by the transfusion of blood as this is associated with increased hypocalcemia. The level of hypocalcemia is said to correlate with the amount of blood products transfused, but the number of units needed to produce a particular degree of hypocalcemia remains to be defined. A standardized value for hypocalcemia due to MTP has yet to be established. Establishing this value would be helpful in determining what level actually affects the rate of mortality. Some studies suggest intravenous calcium supplement should be considered during massive transfusion while others state this does not make a difference.

This data repository will serve as a means to aggregate and analyze best practices as relative to MTP in the trauma patient, with specific interest in component best practices, whole blood protocols, and electrolyte/metabolite replacement.

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • ≥18 years old

  • Included in the Methodist dallas medical center(MDMC) trauma registry
  • Flagged for MTP activation and/or >1unit(U) blood product recorded in the first 24 hours

Exclusion criteria

• • <18 years old