Master Allergen Child Nutrition. Reintroduction of Small Doses (MANOE)

University Hospital, Angers

Status: Unknown

Conditions: Food Allergies

Treatments: Other: allegic food; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02384707

2010-A00448-31

Details and patient eligibility

About

Reintroduction of small doses of food in allergic children to lightening the elimination diet.

Full description

In four groups of allergic children (peanuts, wheat , milk and egg), a reintroduction of 4 small increasing doses of allergen is carried out progressively double-blind placebo- cons , randomized, during a hospitalization.

The procedure for reintroduction of small doses (MPD) is stopped at the appearance of intolerance (in taking a dose of allergen or placebo) defined by the onset of allergic symptoms or objective severe abdominal pain within 45 minutes of taking.

Enrollment: 400 estimated patients

Sex: All

Ages: 9 months to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Allergic children 1 and 16 years for peanut, egg and wheat. So, for milk between 9 months and 16 years.
• Accurate diagnostic
• Allergic react rapidly and acute

Exclusion criteria

• severe disease

Trial design

400 participants in 1 patient group

allergic food

Experimental group

Description:

Reintroduction procedure for small doses : * Administration of the first dose the first dose must be allergic food or placebo * Clinical monitoring for 45 minutes * Administration of the second dose

Treatment:

Other: allegic food

Other: Placebo