Maternal and Fetal Compatibility in Assisted Reproductive Technology (ART)-Oocyte Donor Influences Live Birth Rate

IVI Madrid

Status: Completed

Conditions: Infertility

Treatments: Genetic: KIR HLAC determinations

Study type: Observational

Funder types: Other

Identifiers

NCT02718105

1512-MAD-067-JG

Details and patient eligibility

About

Has the maternal KIR haplotype an impact in pregnancy, miscarriage and live birth rates per embryo transfer in donor oocytes -ART by paternal and oocyte donor HLA-C?

Full description

The combination of maternal KIR haplotype and parental, donors HLA-C, could predict which couple can benefit for the selection of single embryo transfer (SET)/double embryo transfer (DET), or donor selection by HLA-C in ART, in order to increase the live birth rate (LBR)/cycle since HLA-C1/C1 donors are predicted to be safer and C2/C2 males or oocyte donors may be mor "dangerous" as identified by epidemiological studies

Enrollment: 200 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI between 19 - 27 kg/m2
• Blastocyst embryo transfer previous.
• Normal karyotype, thrombophylic and immunological results.
• Normal clinical history, viral serology, hormonal analysis (TSH, T4, prolactin, estrogen, progesterone), spermiogram, sperm FISH and pelvic ultrasound results.

Exclusion criteria

• Pregnancy women.
• Psychiatric disorders.
• Uterus alterations.
• Polycystic ovary syndrome
• Genetic and autoimmune diseases.
• Infectious diseases.
• Corticoid and immunosuppressant treatments previous.

Trial design

200 participants in 1 patient group

Receiver patients in donor oocyte -ART

Description:

Maternal and fetal compatibility KIR HLA-C determinations in ART -oocyte donor

Treatment:

Genetic: KIR HLAC determinations