Maternal and Fetal Outcome of CKD Mother Patient in Sohag Governorate

Sohag University

Status: Enrolling

Conditions: CKD PREGNANT WOMEN

Treatments: Diagnostic Test: Alb /creat ratio or 24h urine protein; Diagnostic Test: Serum creatinine; Diagnostic Test: Abdominal ultrasound; Diagnostic Test: Renal biobsy; Diagnostic Test: Urine analysis; Diagnostic Test: Serum electrolyte; Other: Clinical assesment

Study type: Observational

Funder types: Other

Identifiers

NCT05867459

Soh-Med-23-04-06MS

Details and patient eligibility

About

Aim of the work:

In this study, we aimed:

Is to investigate the following issues: (1) the pregnancy outcomes of patients with CKD (2) additional risk factors for adverse pregnancy outcomes in patients with CKD in the area of sohag governorate.

Full description

prospective observational study including group of pregnant CKD women The Group of pregnant CKD PT as mentioned in introduction and according to KIDOG definition of CKD regardless cause of CKD .

The data will be collected by multiple visit and survey of patient in hemodialysis units in sohag governorate and renal outpatient clinic and obstetric department and internal medicine department in sohag university hospital

Duration of study:

nine month after approval of protocol by medical research committee of sohag faculty of medicine

Data collection procedure:

The following clinical data will be collected:

Clinical assessment:

age, kidney disease history, history of DM or HTN ,history of pregnancy during study, therapy in early pregnancy (including antihypertensive drugs and immunosuppressive agents), , baseline blood pressure, body weight, body height, and . Mean arterial pressure (MAP) was calculated as (systolic pressure+2×diastolic pressure)/3. Body mass index (BMI) was calculated based on height and body weight. According to age and Scr level, the estimated glomerular filtration rate (eGFR) was calculated by CKD-EPI Creatinine Equation (2021)

Evaluation of pregnancy outcomes :Adverse pregnancy outcomes included maternal death, severe preeclampsia ,eclampsia ,duration of hospital stay and type of care need, mode of delivery ,need of blood transfusion , gestational age during delivary for detet preterm birth> 37W early preterm from 28 to 34W or late preterm from 34 to37W or extremely preterm > 28W, birth weigh for low birthweight> 2500 g ,very low birth weight >1500g , extremely low birth weight>1000g,NICU admission,IUGR, still birth ,abortion, and neonatal death.

Laboratory assessment:

1. serum creatinine
2. urine analysis 3-24h protein in urine or albumin create ratio

4-serum electrolyte s.Na s.K ionezed Ca 5-pathological result of renal biopsy if done 6-abdominal ultrasound with full comment on kidney

Enrollment: 30 estimated patients

Sex: Female

Ages: 18 to 52 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All pregnant patients with CKD regardless the cause of CKD in any stage of CKD on dialysis or not.

Exclusion criteria

• Any patient not defined CKD or serum creatinineless than1,2 befor 13W of pregnancy Grand multipara patient with history of multiple abortion or still birth not related to CKD affection period

Trial design

30 participants in 1 patient group

CKD PREGNANT PATIENT

Description:

The Group of pregnant CKD PT as mentioned in introduction and according to KIDOG definition of CKD regardless cause of CKD

Treatment:

Other: Clinical assesment

Diagnostic Test: Serum electrolyte

Diagnostic Test: Renal biobsy

Diagnostic Test: Alb /creat ratio or 24h urine protein

Diagnostic Test: Abdominal ultrasound

Diagnostic Test: Serum creatinine

Diagnostic Test: Urine analysis