Maternal and Offspring Outcomes in Pregnant Women With Pre-existing ASCVD (CVD_OBS)

Samsung Medical Center

Status: Enrolling

Conditions: Pregnancy Complications; Adverse Birth Outcomes; Cardiovascular Diseases; Atherosclerosis; Adverse Cardiac Event

Treatments: Other: Pre-existing atherosclerotic cardiovascular disease

Study type: Observational

Funder types: Other

Identifiers

NCT06406998

CVD_OBS

Details and patient eligibility

About

A growing body of evidence supports associations between cardiovascular health and adverse pregnancy outcome and between adverse pregnancy outcome and atherosclerotic cardiovascular disease and builds on the well-established pathways known to exist between cardiovascular health and atherosclerotic cardiovascular disease across the life course and intergenerationally. Furthermore, previous studies frequently lack comprehensive long-term follow-up, making it difficult to assess the enduring impacts of maternal cardiovascular health on postpartum outcomes and long-term maternal and child health.

Full description

the current study aimed to evaluate the associations between maternal pre-existent atherosclerotic cardiovascular disease and adverse pregnancy outcomes, and the combined effect of maternal pre-existent atherosclerotic cardiovascular disease and adverse pregnancy outcomes on the risk of long-term adverse events of offspring.

Enrollment: 5,461,222 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women with live birth from Korea (between January 1, 2005 to December 31, 2019)

Exclusion criteria

• None

Trial design

5,461,222 participants in 2 patient groups

Pregnant women with pre-existing atherosclerotic cardiovascular disease

Description:

Among the total cohort, pregnant women with pre-existing atherosclerotic cardiovascular disease were selected (N=145,315).

Treatment:

Other: Pre-existing atherosclerotic cardiovascular disease

Matched cohort

Description:

Among the total cohort, 1:4 matched offspring born to women without pre-existent atherosclerotic cardiovascular disease using a propensity score were generated (N=581,260).