Maternal Characteristics Associated With Child Growth and Adiposity

Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri

Status: Enrolling

Conditions: Obesity, Infant; Obesity

Treatments: Other: overweight/obesity

Study type: Observational

Funder types: Other

Identifiers

NCT05798676

L2022

Details and patient eligibility

About

The goal of this observational study is to investigate the concentrations of leptin, insulin, liver expressed antimicrobial peptide 2 (LEAP2), and cortisol in plasma and breast milk and their relationship with eating behavior, growth, adiposity and with the levels of these hormones in infants, comparing mothers with normal weight and with pre-pregnancy overweight/obesity. The main question[s] it aims to answer are:

• Are maternal hormones associated with child growth and adiposity
• Are maternal hormone receptors associated with child growth and adiposity
• Are infant hormones and their receptors associated with child growth and adiposity Participants will provide milk and blood samples. Researchers will compare mothers with normal weight and with pre-pregnancy overweight/obesity to see if there are differences in child growth and adiposity .

Enrollment: 130 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Lactating women with pre-pregnancy normal weight and overweight or obesity as described by the World Health Organization.

Exclusion criteria

• Diabetes (Type I or II or gestational)
• Multiple pregnancy
• Hypertensive disorders during pregnancy
• Delivery of pre-term infant (<37 weeks).

Trial design

130 participants in 2 patient groups

mothers with pre-pregnancy normal weight and their infants

Description:

mothers with pre-pregnancy normal weight according to World Health Organization will provide blood and milk samples

mothers with pre-pregnancy overweight or obesity and their infants

Description:

mothers with pre-pregnancy overweight or obesity according to World Health Organization will provide blood and milk samples

Treatment:

Other: overweight/obesity