Maternal Grandmothers in the Born in Guangzhou Cohort Study (MGBIG)

Guangzhou Women and Children's Medical Center

Status: Enrolling

Conditions: Host and Microbiome; Immune Development; Childhood Obesity; Neurodevelopment; Hereditary Transmission

Study type: Observational

Funder types: Other

Identifiers

NCT03633162

2018041801

81673181 (Other Grant/Funding Number)

201508030037 (Other Grant/Funding Number)

Details and patient eligibility

About

The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.

Full description

It was previously believed that heredity strictly follows Mendel's laws, but recent studies have found that through placental material exchange, mammals may transfer maternal immune-related factors vertically, thus promoting the protection of "non-heredited maternal antigenic traits". Thus, the transmission of reproductive information across generations is realized. Since the unusual genetic pattern of the X chromosome, grandmother's influence may be gender specific. Since grandchildren were usually took care by grandparents in China, it could be achievable to attach and recruit maternal grandmother together with mother and children. Cohort including three generations of women is rare in Asia at present. In the MGBIG, extensive information including demographic characteristics, lifestyle, history of diseases, mental health, and behaviors is collected from the participants. Longitudinal follow up and surveillance of common chronic diseases are also to be conducted. The MGBIG intends to recruit maternal grandmothers to study the effects of maternal genetic and environmental exposure on the health of their children and grandchildren.

Enrollment: 5,000 estimated patients

Sex: Female

Ages: 36 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center
2. Baseline information of maternal grandmother's daughter during pregnancy available

Exclusion criteria

1. Significant cardiovascular abnormalities
2. Intelligent obstacle, intellectual disabilities or gawkish condition