Maternal Inflammatory Parameters Within Routine Treatment With Betamethasone

Medical University of Vienna

Status: Completed

Conditions: Preterm Birth

Study type: Observational

Funder types: Other

Identifiers

NCT02993744

2130/2015

Details and patient eligibility

About

It is the aim of this study to detect the effect of Betamethasone on the maternal inflammatory parameters C-reactive protein (CRP) and leukocytes of a pregnant woman under threat of preterm delivery, for example because of a cervical infection.

Full description

BACKGROUND

Cortisone influences the maternal number of leukocytes and CRP of a pregnant woman. Because of that, it is difficult to know if the medical treatment of an infection was successful and accordingly if the diagnosis was justified.

METHODS

In this study, the blood results of 75 pregnant women under threat of preterm delivery (week of gestation 23+0 to 34+6), treated with Betamethasone will be analysed. 65 pregnant women without complications serve as control group.

Enrollment: 140 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• week of gestation 23+0 until 34+6

Exclusion criteria

• infectious diseases f.e. hepatitis B or C, HIV

• diseases of the thyroid gland

  75 Patients facing preterm labour 65 Patients acting as a control group, without preterm labor

Trial design

140 participants in 2 patient groups

Case Group

Description:

75 woman between the age of 18 to 50 years, week of gestation 23+0 - 34+6, threatening preterm delivery, application of Betamethasone

Control Group

Description:

65 woman between the age of 18 to 50 years, week of gestation 23+0 - 34+6, no threatening preterm delivery