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Matrix Metalloproteinases's in Oral Biofluids During Pregnancy and Postpartum

A

Aydin Adnan Menderes University

Status

Completed

Conditions

Pregnancy

Treatments

Other: Saliva collection
Other: GCF collection

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of MMP-8, MMP-9 and TIMP-1 during 2/3 trimester of pregnancy and after delivery

Full description

MMP-8 and MMP-9 have been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. The balance between tissue inhibitors of metalloproteinases (TIMPs) and MMPs play an important role in maintaining the integrity of healthy periodontium.

Enrollment

114 patients

Sex

Female

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Pregnant group included women, who were in their second trimester (weeks 16-24) and third trimester (weeks 25-34)

Exclusion criteria

  • (a) any known systemic disease, (b) periodontal treatment within the last six months, (c) patients having less than 10 teeth, (d) smokers and (e) individuals with BMI > 30 kg/m2

Trial design

114 participants in 3 patient groups

Pregnancy group
Description:
Pregnant group included women, who were in their second trimester (weeks 16-24) and third trimester (weeks 25-34)
Treatment:
Other: GCF collection
Other: Saliva collection
Postpartum group
Description:
Postpartum group included women, who were evaluated 6 months after giving birth
Treatment:
Other: GCF collection
Other: Saliva collection
Non-pregnant group
Description:
Women who were systemically healthy and non-pregnant.
Treatment:
Other: GCF collection
Other: Saliva collection

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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