Matrix Metalloproteinases's in Oral Biofluids During Pregnancy and Postpartum

Aydin Adnan Menderes University

Status: Completed

Conditions: Pregnancy

Treatments: Other: Saliva collection; Other: GCF collection

Study type: Observational

Funder types: Other

Identifiers

NCT03516565

BAP-18

Details and patient eligibility

About

The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of MMP-8, MMP-9 and TIMP-1 during 2/3 trimester of pregnancy and after delivery

Full description

MMP-8 and MMP-9 have been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. The balance between tissue inhibitors of metalloproteinases (TIMPs) and MMPs play an important role in maintaining the integrity of healthy periodontium.

Enrollment: 114 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pregnant group included women, who were in their second trimester (weeks 16-24) and third trimester (weeks 25-34)

Exclusion criteria

• (a) any known systemic disease, (b) periodontal treatment within the last six months, (c) patients having less than 10 teeth, (d) smokers and (e) individuals with BMI > 30 kg/m2

Trial design

114 participants in 3 patient groups

Pregnancy group

Description:

Pregnant group included women, who were in their second trimester (weeks 16-24) and third trimester (weeks 25-34)

Treatment:

Other: GCF collection

Other: Saliva collection

Postpartum group

Description:

Postpartum group included women, who were evaluated 6 months after giving birth

Treatment:

Other: GCF collection

Other: Saliva collection

Non-pregnant group

Description:

Women who were systemically healthy and non-pregnant.

Treatment:

Other: GCF collection

Other: Saliva collection