Maturational Changes in Cardiac Structures -- Blood Pressure Relationship -- SCOR in Hypertension

National Institutes of Health (NIH) logo

National Institutes of Health (NIH)

Status

Completed

Conditions

Hypertension
Cardiovascular Diseases
Heart Diseases

Study type

Observational

Funder types

NIH

Identifiers

NCT00005469
4914
P50HL044546 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

To examine a school-based population of children for maturational changes in blood pressure and cardiac structures.

Full description

BACKGROUND: Although excessive left ventricular mass has been viewed as an adaptation to increased blood pressure, it can precede the rise in blood pressure in hypertensive models. Excessive growth of the heart may reflect additional factors contributing to eventual level of blood pressure. In children, rapid heart growth may be predictive of subsequent high childhood blood pressure level and greater incidence of cardiovascular disease in adult relatives. These studies had the potential of defining maturational changes in known risk factors which might help predict future hypertensive disease. The study was a subproject within a Specialized Center of Research (SCOR) in Hypertension. The Request for Applications for the SCOR was released in October, 1988. DESIGN NARRATIVE: A total of 124 prepubertal males and females were followed longitudinally for five years. Yearly examinations defined the stages of sexual maturation. On four occasions each year, subjects were studied for resting and ambulatory blood pressure, echocardiography, anthropometry and activity assessment. Once yearly, each subject had blood drawn for hormone analyses and whole blood viscosity estimate. From these data, growth velocities of the heart and rate of change of blood pressure were determined. These parameters were analyzed to determine if rapid growth of the heart preceded or followed the rise in blood pressure observed during puberty and body size and composition, sexual maturation and hormone changes, and sympathetic activity. The study was a subproject within a SCOR in Hypertension. Approximately 7 percent of total dollars were awarded for this subproject. The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Sex

Male

Ages

Under 100 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

No eligibility criteria

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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