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Maximal Exercise Capacity at 2500 m of High Altitude

University of Zurich (UZH) logo

University of Zurich (UZH)

Status

Completed

Conditions

Maximal Exercise Capacity
High Altitude Pulmonary Hypertension

Treatments

Procedure: Maximal Exercise Capacity

Study type

Interventional

Funder types

Other

Identifiers

NCT05264324
OVERALP II D

Details and patient eligibility

About

The impact of hypoxia on maximal work rate during incremental ramp exercise within 3-6 hours after arriving at 2500m of high altitude in patients with precapillary pulmonary hypertension

Enrollment

28 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Informed consent as documented by signature (Appendix Informed Consent Form)
  • PH class I (PAH) or IV (CTEPH) diagnosed according to guidelines: mean pulmonary artery pressure >20 mmHg, pulmonary vascular resistance ≥3 wood units, pulmonary arterial wedge pressure ≤15 mmHg during baseline measures at the diagnostic right-heart catheterization

Exclusion criteria

  • resting partial pressure of oxygen <8 kilopascal at Zurich at 490 m low altitude
  • exposure to an altitude >1000 m for ≥3 nights during the last 2 weeks before the study
  • inability to follow the procedures of the study
  • other clinically significant concomitant end-stage disease (e.g., renal failure, hepatic dysfunction)

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

28 participants in 2 patient groups

High altitude 2500 m above sea level (high altitude)
Experimental group
Description:
Maximum Exercise Capacity in high altitude
Treatment:
Procedure: Maximal Exercise Capacity
Low altitude 470 m above sea level (low altitude)
Active Comparator group
Description:
Maximum Exercise Capacity in low altitude
Treatment:
Procedure: Maximal Exercise Capacity

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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