Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics

University of Arkansas

Status: Completed

Conditions: Sarcopenia

Treatments: Other: Recommended Dietary Allowance of Protein; Other: Habitual protein intake; Other: Optimal Protein Intake

Study type: Interventional

Funder types: Other

Identifiers

NCT04830514

262424

Details and patient eligibility

About

A randomized study to demonstrate how animal-based protein-rich food sources can be used by older adults to increase protein intake within pre-existing dietary patterns.

Full description

Current dietary patterns of older Americans will be augmented by readily available quality protein sources. Investigators will observe the effects of recommended and common protein intakes on the maintenance of whole-body protein balance and potential for muscle protein anabolism.

3 groups of 10 older subjects will be studied during daily protein intakes. Study duration per subject will be about 2 weeks.

Enrollment: 44 patients

Sex: All

Ages: 50 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI ≤ 35 kg/m2
• Capable of providing informed consent
• COVID-19 negative and/or asymptomatic

Exclusion criteria

• Subject who does not/will not eat animal protein sources.
• Body mass index > 35.
• History of chemotherapy or radiation therapy for cancer in the 6 months prior to enrollment.
• Use of insulin to control blood sugar level.
• Currently receiving androgen (e.g., testosterone) or anabolic (e.g., GH, IGF-I) therapy.
• Currently using prescription blood thinning medications.
• Unable or unwilling to suspend aspirin use for 7 days prior to Visit 3.
• Unwilling to avoid using protein or amino-acid supplements during participation.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

44 participants in 3 patient groups

Recommended dietary allowance (RDA) for protein

Experimental group

Description:

(RDA; 0.8g/kg/day) Protein intakes will be structured within two meals per day. A 2-day dietary lead-in will precede each dietary intervention. Study duration per subject will last about two weeks.

Treatment:

Other: Recommended Dietary Allowance of Protein

Habitual protein intake consistent with population level norms

Experimental group

Description:

(NHANES; 1.0g/kg/day) Protein intakes will be structured within two meals per day. A 2-day dietary lead-in will precede each dietary intervention. Study duration per subject will last about two weeks.

Treatment:

Other: Habitual protein intake

Optimal protein intake (OPI)

Experimental group

Description:

(OPI; 1.5g/kg/day) Protein intakes will be structured within two meals per day. A 2-day dietary lead-in will precede each dietary intervention. Study duration per subject will last about two weeks.

Treatment:

Other: Optimal Protein Intake