Maximum Expiratory Pressure in Induced Cough as a Predictor of Extubation Failure

Hospital Nacional Profesor Alejandro Posadas

Status

Completed

Conditions

Airway Extubation

Treatments

Diagnostic Test: MEPic

Study type

Interventional

Funder types

Other

Identifiers

NCT04356625

209LUP0S0/18

Details and patient eligibility

About

Clinical trial for the evaluation of diagnostic tests. The sample was composed of adults under mechanical ventilation who passed the spontaneous breathing trial and was ready to be extubated. The maximum expiratory pressure measured in the usual way and the maximum expiratory pressure generated during the induced cough were taken as predictor variables. The outcome variable was extubation failure, measured at 72 hours and at 7 days.

Full description

After completing the spontaneous breathing trial (SBT), with the extubation decision defined by the physician in charge of the patient and maximal expiratory pressure (MEP) as usually measured greater than 30 centimeters of water (cmH2O). Following this, the patient was allowed to rest for 5 minutes in the same condition. With the patient in the supine position sitting 45 ° to 60 °, the closed suction catheter was removed, an elbow was placed at 90 ° and a bacterial filter in series with the endotracheal tube (ET), an adapter was also coupled with a outlet port to the aneroid pressure gauge. In series an inspiratory unidirectional valve was placed that did not allow expiration. Immediately 2 ml of physiological solution was slowly instilled through the port in the 90º elbow to trigger the cough reflex. The presence or absence of reflex cough and the MEP during induced cough (MEPic) value were verified.

As a safety method, the procedures were stopped if the patient presented signs of intolerance such as respiratory rate (RF)> 35 breaths per minute, saturation <90%, heart rate (HR)> 140 beats per minute or increase of 20 % of resting levels.

Enrollment

80 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Under mechanical ventilation via endotracheal tube in a period greater than 48 hours
Passing the spontaneous breathing trial an be ready for extubation.
Agree to participate in the study and sign the informed consent by the patient or family member

Exclusion criteria

tracheostomized prior to admission to mechanical ventilation
history of neuromuscular disease
presence of unstable heart disease
received upper digestive surgery
presence of uncontained enterocutaneous fistula
candidates for non-invasive ventilation as a modality of interface exchange for extubation or as a preventive modality
patients who did not reach a MEP (habitual) of 30 cmH20 since they are not extubated by the extubation protocol of our institution.