MCG for Localization of Tachyarrhythmia's Origin

Shandong University

Status: Enrolling

Conditions: Atrial Tachycardia; Atrial Fibrillation; Atrial Flutter; Paroxysmal Supraventricular Tachycardia; Premature Ventricular Contraction; Tachyarrhythmia

Treatments: Device: Magnetocardiography

Study type: Interventional

Funder types: Other

Identifiers

NCT06327425

MCG-Tachyarrhythmia

Details and patient eligibility

About

This is an exploratory research aiming to accurately identify the site of origin of tachyarrhythmia using Magnetocardiography (MCG), which will have guiding significance for early diagnosis, the formulation of treatment plans and preoperative positioning for radiofrequency ablation.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18 to 79 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-79 years old;
• Those whose conditions are comparatively stable and who have been diagnosed by an attending physician （or physicians with higher qualifications） with paroxysmal supraventricular tachycardia, atrial tachycardia, atrial flutter, atrial fibrillation, or premature ventricular contractions, and who are capable of performing MCG and cardiac electrophysiologic examinations after evaluation.
• Signed informed consent.

Exclusion criteria

• Those with known structural heart disease such as cardiomyopathy and valvular disease;
• Those with history of other cardiovascular diseases such as pulmonary embolism and aortic dissection;
• Those with connective tissue diseases (lupus erythematosus, rheumatoid arthritis, dermatomyositis, polyarteritis nodosa, etc.) combined with cardiac complications;
• Those with obvious abnormal thyroid function, severe anemia or other blood diseases and other diseases that obviously affect the circulating blood supply;
• Those with Obese (BMI>30kg/cm2) or underweight (BMI<18kg/cm2);
• Those with malignant tumors;
• Professional athletes, pregnant or breastfeeding women, alcoholics;
• Those with acute diseases or critical illnesses in other systems, such as acute or severe respiratory diseases, abnormal liver function or renal function, etc.;
• Those with infectious diseases or communicable diseases;
• Those who are unable or fail to perform magnetocardiography due to claustrophobia, physical impairment, etc.;
• Unable to or fail to cooperate with the corresponding research requirements.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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1,000 participants in 2 patient groups

Patients with atrial tachycardia

Experimental group

Description:

Patients with atrial tachycardia will receive dynamic ECG, MCG and cardiac electrophysiologic examinations.

Treatment:

Device: Magnetocardiography

Patients with atrial flutter

Experimental group

Description:

Patients with atrial flutter will receive dynamic ECG, MCG and cardiac electrophysiologic examinations.

Treatment:

Device: Magnetocardiography