Mean Arterial Pressure Reduction Anesthesia Induction Using Propofol Bolus or Tritiated Target-infusion

Brasilia University Hospital

Status and phase: Unknown; Phase 4

Conditions: Hypotension on Induction; Hypnotic Intoxication

Treatments: Drug: Propofol Injection [Diprivan]; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT04291794

tccgui2019

Details and patient eligibility

About

To compare haemodynamics and bispectral index values between conventional bolus propofol induction and target-controlled propofol infusion.

Full description

To compare mean arterial pressure, heart rate and bispectral index values between conventional bolus propofol induction and target-controlled propofol infusion.

Enrollment: 120 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Scheduled for general anesthesia;
• No contraindication for propofol.

Exclusion criteria

• Data loss;
• Protocol violation.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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120 participants in 2 patient groups

Conventional bolus induction

Active Comparator group

Description:

Hypnotic component of general anesthesia induction will be a single bolus of propofol 2mg/kg followed by turning on sevoflurane 2% at a fresh gas flow of 2L/min.

Treatment:

Drug: Propofol

Target-controlled induction

Experimental group

Description:

Hypnotic component of general anesthesia induction will be target-controlled propofol infusion tritiated to loss of consciousness. Propofol target-controlled infusion will be maintained.

Treatment:

Drug: Propofol Injection [Diprivan]